Case 15

Presentation:


A 9 year old spayed female poodle was presented to AcaseAweek Clinic with a one month history of bloody urine which has progressively gotten worse in the past 2 weeks. The owner claims to have seen blood clots passed in the urine recently. The patient has not been eating well for the past 2 days and has vomited 4 times in the past 24 hours. Animal is unvaccinated and has no history of flea or heartworm prevention. Dog is fed home-made food. 


Physical exam:
  • Weight: 7.04 kg 
  • Temperature: 105.2 F
  • Pulse: 112 bpm
  • RR: 54 
  • MM: pale
  • CRT: 2 sec


Complete Blood Count:
  • Hct: 27% (37-55)
  • RBC: 5.2 x109/L (5.5-8.5)
  • Hb: 10.3 g/dL (12-18)
  • WBC: 3.2 x 109/L (6-16.9)
  • Grans: 1.7 x 109/L (3.3-12)
  • PLT: 374 x 109/L (175-500)
  • TP: 9 g/dL (5.2-8.2)
  • nRBC : 1%


Biochemistry Profile:
  • AP: 65 U/L (23-212)
  • ALT: 35 U/L (10-100)
  • Glob: 4.9 g/dL (2.5-4.5)
  • Alb: 2.6g/dL (2.7-3.7)
  • BUN 33 mg/dL (7-27)
  • CREA 1.3 mg/dL (0.5-1.8)


Urinalysis:
  • Colour: Red
  • Odour: Strong
  • Turbidity: 3+
  • G: 1.019
  • pH: 8.5
  • Glucose: -ve
  • Bilirubin: -ve
  • Ketones: -ve
  • Protein: 4+
  • Blood: 3+
  • RBC: 3+
  • WBC: 3+
  • Squamous: few
  • Transitional epi: -ve
  • Tubular epi: -ve
  • Bacteria: 3+
  • Casts: -ve
  • Crystals: 2+ (struvite)


Abdominal radiographs were taken as shown below (click on the image to enlarge):


What are radiographic findings?
What is your diagnosis?
What further diagnostic tests will you perform?
How will you treat and manage this case?

Solution for Case 14

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Radiographs show reverse ‘D’ appearance of heart on VD/DV views. Enlargement of right ventricle on lateral view. Enlargement of main pulmonary artery and tortuous appearance of pulmonary arteries.


Diagnosis: Heartworm disease


Differentials for the signs presented:
  • Dilated Cardiomyopathy
  • Congestive Heart Failure (Right-sided)
Further diagnostic tests:
  • Heartworm snap test
  • Echocardiography
  • CBC, Chemistry and urinalysis.
Radiographic findings are suggestive of heartworm disease. 2/6 Right AV systolic murmur may be due to heartworm disease. Other causes of the murmur could be dilated cardiomyopathy or congestive heart failure. Murmurs are caused by turbulent blood flow through the heart and vessels, a grade 2 murmur is a faint murmur restricted to a localized area.


Dilated cardiomyopathy (DCM) is an acquired disease characterized by progressive loss of cardiac contractility, ultimately leading to both left and right-sided congestive heart failure. It was ruled out based on radiographic findings.


Congestive heart failure (CHF) results in pulmonary edema (left-sided heart failure) or ascites (right-sided heart failure). With DCM and CHF, tachycardia is usually present. The absence of pulmonary edema and/or ascites rule out dilated cardiomyopathy and congestive heart failure.


Definitive diagnosis is heartworm disease based on thoracic radiographs and a positive heartworm test.


Treatment:
  • Prednisone 0.5mg/kg PO EOD for 10 days to combat any inflammation and as preventative for pulmonary thromboembolism.
  • Immiticide treatment- alternative dosing: 1 injection of Melarsomine HCL 2.5mg/kg deep IM, repeat injection in 1 month with 2 injections 24 hours apart.
  • A month after the third injection, give heartworm prevention.
  • Heartworm test 4 months after second set of immiticide injections.
  • Monitor for pulmonary thromboembolism, possibly administer anticoagulants. 
  • Strict cage rest while being treated.
  • Monitor heart rate, respiration and attitude.