Solution to case 20

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Tentative diagnosis: FIV/FeLV

Differentials: FIV, FeLV, hemobartonella, cytoxazoon, Eosinophilic granuloma complex, superficial pyoderma, IMHA, hyperthyroidism, renal disease. 

Further diagnostic tests:IDEXX Combo FIV/FeLV snap test, blood smear for blood protozoa, impression smear of the oral lesions, skin scraping and bacterial culture and sensitivity for the skin lesions. T4 test. PCR test for hemobartonella is also available. 

In this case the IDEXX combo test was positive for FeLV. No blood protozoa was seen on the blood smear. No eosinophils were seen on the impression smear of the oral cavity. Skin scraping was negative. Culture for skin lesions was positive for Staph infection and sensitive to Potentiated Amoxicillin. T4 levels were normal.

Based on the clinical signs and results from CBC and IDEXX snap test, FeLV is at the top of the differential list.  Her general appearance, lethargy, skin condition and lymphadenopathy all are signs that the immune system is not functioning optimally. Increase in the BUN/Creatinine and total proteins is due to dehydration. 

FeLV is a retrovirus in the same family as HIV/AIDS in humans.  It is more common in outdoor cats and kittens.  It is transmitted primarily through saliva from sharing utensils or from bite wounds and licking.  It can also be transmitted via urine, tears, feces, milk and through placenta.   Its main effect is suppression of the immune system thus affected individuals have many other organ system issues. 30% of animals develop cancer (lymphosarcoma).  This virus also leads to bone marrow suppression thus this animal had non-regenerative anemia, leucopenia and thrombocytopenia. Animals can live for years with the disease but usually by the time the diagnosis is made, the cat is already viremic.  Expected lifespan is 1-2 years after diagnosis.
IDEXX combo snap test for FeLV needs to be repeated in six weeks or Immunoflourecent Antibody (IFA) test needs to be done to confirm the diagnosis.  

Treatment Plan:
Blood transfusion was done and supportive therapy was provided as follows:  
IV fluids - LRS
Antibiotics - Potentiated Amoxicillin
B-complex
a/d Hills diet (high nutrition diet for recovering sick animals)

Advised to keep the cat indoors and prevent being around others both so they are not possibly exposed to FeLV. Any secondary infections should be treated as soon as possible. FeLV in this case was repeated in six weeks and was still positive thus confirming the diagnosis.

Case 20

A 2.5 year old female spayed DSH outdoor was presented to the AcaseAweek Clinic with a five week history of lethargy, has not been eating for the past 2 days, and has many areas of alopecia accompanied by pruritis.  She is not up to date on vaccines nor is she on heartworm preventative.  She was given pyrantel 3 days ago.

Physical Exam:Weight = 2.2kg
Temp = 101.5
HR/Pulse = 204
RR = 36
General appearance: “scruffy” and unkempt
MM: pale but moist
Oral: Halitosis and stomatitis
CV: Tachycardia but strong pulse
Integument: Areas of alopecia on right lateral stifle, along dorsal spine, left abdomen, dorsal neck with associated areas of scabbing and pustules. Entire head had short fur and dry underlying skin.  
Musculoskeletal: Thin, BCS 2/5
Ears: Black/brown debris in both ears
Eyes: 3rd eyelids prolapsed
Lymph nodes: Superficial lymph nodes were reactive

CBC and Chemistry:
PCV = 9.8% (24-45)
Hb = 3.1 g/dl (8-15)
Granulocytes = 2.0x109/L (2.5-12.5)
Platelets = 21 x109/L (175-500)
BUN = 41 mg/dl (18-33)
Creatinine: 2.5 mg/dl (1.1-1.2)
Total protein = 9 g/dl (6.6-8.4)
Other values within normal limits

Urinalysis:
Appearance = normal
SG = 1.026
No other abnormality noticed in UA.



What is your tentative and differential diagnosis?
What further diagnostic tests you will perform?
What will be your treatment plan?

Solution to this case